Full coverage: 50 Dead in Orlando Nightclub Shooting

The Orlando shooting has a bearing on the 2016 presidential election campaign. Candidates have connected the incident to their policies, particularly on immigration and gun control.

Republican Donald Trump placed responsibility at the feet of radicals and vowed to ban Muslim immigrants. While Democrat Hillary Clinton warned against demagoguery. Referring to so-called "lone wolf" attacks, Clinton said the US was facing what she called a "twisted ideology" and "poisoned psychology".

Donald Trump accused Hillary Clinton of downplaying the threat of terrorism, and again vowed to temporarily block Muslims from entering the United States.

"When I'm elected, I will suspend immigration from areas of the world where there is a proven history of terrorism against the United States, Europe or our allies until we fully understand how to end these threats," Trump said.

Clinton calls this proposal inflammatory.

"Threatening to ban families and friends of Muslim Americans plus millions of Muslim business people and tourists from entering our country hurts the vast majority of Muslims who love freedom and hate terror," Clinton said.

Trump criticized the language Clinton has used to describe some terrorist attacks.

"Hillary Clinton, for months and despite so many attacks, repeatedly refused to say the words radical Islam until I challenged her," Trump said.

On Sunday, Clinton did begin using that phrase and seems to have adopted a harder line.

"We do have enemies who use their distorted version of Islam to justify slaughtering innocent people. They'd take us all back to the Stone Age if they could," Clinton  said.

Trump promised to ensure continued access to guns in the U.S., while Clinton called for more restrictions. A weary sounding U.S. President Barack Obama acknowledged that solutions likely won't come during his remaining months in office.

"The danger here is that then it ends up being the usual political debate and the NRA and the gun control folks say Obama doesn't want to talk about terrorism, and if you talk about terrorism people say why aren't you looking at issues of gun control," Obama said.

Trump and Clinton did agree on one thing: both expressed support for the LGBT members targeted in the attack.